Research Library

Peer-Reviewed Evidence

A curated collection of key research papers supporting the clinical value of central blood pressure measurement and Pulse Wave Analysis technology.

Central blood pressure: current evidence and clinical importance

European Heart Journal, 2014

Comprehensive review demonstrating that central blood pressure is a stronger predictor of cardiovascular events than brachial blood pressure, with implications for diagnosis and treatment of hypertension.

Inflammation and Cardiovascular Disease: 2025 ACC Scientific Statement

Journal of the American College of Cardiology (JACC), 2025

Landmark ACC Scientific Statement confirming that chronic, low-grade inflammation is central to the development and progression of cardiovascular disease, and that inflammatory risk must now be measured, monitored, and treated as part of standard cardiovascular prevention and care.

Association of Central Versus Brachial Blood Pressure With Target-Organ Damage: Systematic Review and Meta-Analysis

Hypertension (AHA), 2016

Systematic review and meta-analysis establishing that central blood pressure is more strongly associated with target-organ damage than brachial blood pressure across multiple indices including left ventricular mass, carotid intima-media thickness, and pulse wave velocity.

Arterial stiffness and cardiovascular events: the Framingham Heart Study

Circulation, 2010

Large-scale population study from the Framingham Heart Study demonstrating that higher aortic stiffness, assessed by pulse wave velocity, is associated with increased cardiovascular risk and improves risk prediction when added to standard risk factors.

Evaluation of a novel sphygmomanometer, which estimates central aortic blood pressure from analysis of brachial artery suprasystolic pressure waves

Journal of Hypertension, 2012

Validation study of the Uscom BP+ device (then branded Pulsecor) against invasive catheter measurement of central aortic blood pressure, demonstrating good correlation between non-invasive suprasystolic oscillometric estimates and direct catheter measurements.

Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study

Hypertension (AHA), 2007

Landmark study from the Strong Heart Study demonstrating that non-invasively determined central pulse pressure is more strongly related to vascular hypertrophy, extent of atherosclerosis, and cardiovascular events than brachial blood pressure.

Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis

European Heart Journal, 2010

Meta-analysis of 11 longitudinal studies demonstrating that central haemodynamic indices are independent predictors of future cardiovascular events and all-cause mortality.

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